300-400 kDa Hyaluronic Acid is Processed by Intestine Microbes to Scale back Irritation
Researchers right here notice that particular species within the intestine microbiome react to some types of hyaluronic acid by rising manufacturing of a metabolite that reduces irritation within the physique. That is possible one in all many such discoveries ready to be made, as researchers try to uncover particular mechanisms by which the intestine microbiome can have an effect on well being. It stays the case that short-cuts exist for many who do not need to wait on a extra full understanding of those mechanisms. For instance, resetting an aged intestine microbiome to a younger configuration through fecal microbiota transplantation from a wholesome younger donor is one method to bypass an absence of particular data as to what precisely has change into much less optimum within the aged intestine microbiome.
On this research, the analysis crew centered on investigating the impact of hyaluronic acid with varied molecular weights. Using a mix of multi-mannequin and multi-omics applied sciences, the researchers established that hyaluronic acid with a selected molecular weight (300-400 kDa) can considerably mitigate inflammatory responses in mice. This impact relies on intestine Bacteroides thetaiotaomicron and Bacteroides caccae, together with their essential metabolite – myristic acid.
The analysis crew discovered that hyaluronic acid stimulates Bacteroides to supply myristic acid, which in flip inhibits the NF-κB signaling pathway, thereby lowering mobile irritation. This research recognized the optimum molecular weight vary of hyaluronic acid to enhance host irritation, elucidated the fabric foundation and molecular mechanisms of intestine impact strains, offered biomarkers for dietary polysaccharide methods to alleviate host irritation, and supplied new methods and insights for the environment friendly screening of microbiota-directed meals.
